Originally named Little Brittany, it was settlers from Brittany in the east of modern France that inhabited the area where the street can be found after the Norman Conquest. Foremost among them apparently was the Duke of Brittany who apparently had a house here prior to the 1500s.
Between the late 15th century and early 18th century, the street was known as a location for booksellers (it was here that Britain’s first daily newspaper, the early 18th century Daily Courant, was printed in the area after moving from Fleet Street).
Famous residents over the years have included the 17th century poet John Milton (there’s also a much-repeated anecdote that has a Little Britain-based bookseller trying to convince the Earl of Dorset to buy as many copies of the apparently immoveable Paradise Lost as he could carry) , a very young Samuel Johnson (the then three-year-old and his mother lodged with a bookseller when she brought him to be touched by Queen Anne as a cure for his scrofula), and Benjamin Franklin who stayed here in 1724.
Literary references included a mention in Charles Dickens’ Great Expectations – the office of the lawyer Mr Jaggers were placed here.
St Bartholomew’s Hospital now occupies many of the buildings in the street.